AutoHotkey
AutoHotkey is a free, open-source scripting language for Windows that allows users to easily create small to complex scripts for all kinds of tasks such as: form fillers, auto-clicking, macros, etc.
Simple shortcut manager for OS X 10.8 or higher.
icanhazshortcut simple shortcut manager for OS X
hotkeys productivity-tool shortcuts
AutoHotkey is a free, open-source scripting language for Windows that allows users to easily create small to complex scripts for all kinds of tasks such as: form fillers, auto-clicking, macros, etc.
Free Open Source Windows
Quicksilver is a fast and free Mac OS X productivity application that gives you the power to control your Mac quickly and elegantly. Quicksilver learns your habits, making your everyday chores simple and efficient.
Free Open Source Mac OS X
Keyboard Maestro enables you to create or record custom macro shortcuts that you can activate at any time.
Commercial Mac OS X
This is a tool for powerful automation of OS X. At its core, Hammerspoon is just a bridge between the operating system and a Lua scripting engine.
Free Open Source Mac OS X
Spark is a powerful and easy shortcuts manager. With Spark you can create Hot Keys to launch applications and documents, execute AppleScripts, command iTunes, and more...
Free Mac OS X
A free light weight mouse macro that records mouse movements, clicks and keyboard entries. Mini Mouse Macro is totally free, no adds, no banners, no trial, free.
Free Windows